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<article documenttype="Original" productfree="no" id="a010742" articleid="010742" coverdate="January 2012" copyrighttf="no" copyrightowner="Sami W. Serafi" doi="10.3402/jchimp.v1i4.10742" tagger="Datapage" numcolorpages="0" yearofpub="2012" xml:lang="en">
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		<journalcode>JCHIMP</journalcode>
		<issn type="print"/>
		<issn type="electronic">2000-9666</issn>
		<coden>Journal of Community Hospital Internal Medicine Perspectives Vol. 1, January 2012, pp. 1&ndash;2</coden>
		<sici>sici</sici>
		<pubitemid>xxx</pubitemid>
		<pubmedabbrev>PUBMED Abbreviation</pubmedabbrev>
		<author primaryauthor="yes" corresponding="yes" seq="1">
			<name>
				<givenname>Sami</givenname>
				<inits>W.</inits>
				<surname>Serafi</surname>
				<degree>BA</degree>
			</name>
			<contactinfo>
				<contact corresponding="no" postpub="no" biocontact="no">
					<position affilref="AF0001" primaryaffiliation="yes"/>
				</contact>
				<contact corresponding="yes" postpub="no" biocontact="no">
					<address>
						<usa>
							<addline>*Sami W. Serafi, American University of Antigua, Union Memorial Hospital</addline>
							<city>Baltimore</city>
							<state>MD</state>
							<country>USA</country>
							<email url="samiserafi@gmail.com"/>
						</usa>
					</address>
				</contact>
			</contactinfo>
		</author>
		<author primaryauthor="no" corresponding="no" seq="2">
			<name>
				<givenname>Crystal</givenname>
				<surname>Vliek</surname>
			</name>
			<contactinfo>
				<contact corresponding="no" postpub="no" biocontact="no">
					<position affilref="AF0002" primaryaffiliation="yes">
						<affiltitle>MD</affiltitle>
					</position>
				</contact>
			</contactinfo>
		</author>
		<author primaryauthor="no" corresponding="no" seq="3">
			<name>
				<givenname>Mahnaz</givenname>
				<surname>Taremi</surname>
			</name>
			<contactinfo>
				<contact corresponding="no" postpub="no" biocontact="no">
					<position affilref="AF0003" primaryaffiliation="yes">
						<affiltitle>MD</affiltitle>
					</position>
				</contact>
			</contactinfo>
		</author>
		<affiliations>
			<affiliation id="AF0001">
				<institution>
					<department>Union Memorial Hospital</department>
					<institutionname>American University of Antigua</institutionname>
				</institution>
				<address>
					<usa>
						<addline/>
						<city>Baltimore</city>
						<state>MD</state>
						<country>USA</country>
					</usa>
				</address>
			</affiliation>
			<affiliation id="AF0002">
				<institution>
					<department>Union Memorial Hospital</department>
					<institutionname>Department of Cardiology</institutionname>
				</institution>
				<address>
					<usa>
						<addline/>
						<city>Baltimore</city>
						<state>MD</state>
						<country>USA</country>
					</usa>
				</address>
			</affiliation>
			<affiliation id="AF0003">
				<institution>
					<department>Union Memorial Hospital</department>
					<institutionname>Department of Medicine</institutionname>
				</institution>
				<address>
					<usa>
						<addline/>
						<city>Baltimore</city>
						<state>MD</state>
						<country>USA</country>
					</usa>
				</address>
			</affiliation>
		</affiliations>
		<search>
			<category/>
			<primarysubcategory/>
			<subcategory/>
			<subcategory/>
			<topic/>
			<subtopic/>
			<subtopic/>
		</search>
		<production-dates acceptdate="28Nov2011" receiveddate="11Oct2011" reviseddate="15Nov2011" webpubdate="26Jan2012"/>
	</meta>
	<journaltitle>Journal of Community Hospital Internal Medicine Perspectives</journaltitle>
	<supertitle>ORIGINAL ARTICLE</supertitle>
	<title>Osborn waves in a hypothermic patient</title>
	<shorttitle>Osborn waves in a hypothermic patient</shorttitle>
	<intro/>
	<section1>
		<title/>
		<para>A 56-year-old man presented with hypothermia (rectal temperature of 30.1&deg;C) and hypotension after being found by emergency medical services (EMS) on his basement floor. A 12-lead electrocardiogram (ECG) revealed normal sinus rhythm with a rate of 62 bpm, right bundle branch block, prolonged QT interval (QTc of 564 ms), wide QRS (110 ms), and a prominent J wave in the precordial leads (<figureref linkend="F0001">Fig. 1</figureref>). After the patient was warmed to a normal core body temperature, hydrated, and made normotensive, repeat ECG showed a normal sinus rhythm of 79 bpm, right bundle branch block, prolonged QT (QTc of 488), and resolution of the J waves (<figureref linkend="F0002">Fig. 2</figureref>).</para>
		<figure id="F0001" articleid="10742" productid="JCHIMP" doi="10.3402/jchimp.v1i4.10742-F0001" colorgraphics="no">
			<title>Fig. 1.&emsp;</title>
			<caption>Osborn waves on admission ECG can be seen clearly in the precordial leads. Arrows point to Osborn waves.</caption>
			<graphic entityref="F0001"/>
		</figure>
		<figure id="F0002" articleid="10742" productid="JCHIMP" doi="10.3402/jchimp.v1i4.10742-F0002" colorgraphics="no">
			<title>Fig. 2.&emsp;</title>
			<caption>Osborn waves resolved 48 hours after admission.</caption>
			<graphic entityref="F0002"/>
		</figure>
		<para>The J wave is also known as an Osborn wave, camel-hump sign, late delta wave, hathook junction, and hypothermic wave <citationref linkend="CIT0001">1</citationref>. The prominent J deflection attributed to hypothermia was first reported in 1938 by Tomaszewski. Over time, the wave has increasingly been referred to as an Osborn wave, in most part due to Osborn&apos;s 1953 article in the <i>American Journal of Physiology</i> on experimental hypothermia <citationref linkend="CIT0002">2</citationref>.</para>
		<para>An Osborn wave is characterized as an extra deflection of the terminal junction of the QRS complex and the start of the ST segment <citationref linkend="CIT0003">3</citationref>. Typically, the deflection at the J point is in the same direction as that of the QRS complex <citationref linkend="CIT0004">4</citationref>. It is more commonly observed in leads II, III, AVF, V5, and V6. The J wave disappears with normothermia <citationref linkend="CIT0005">5</citationref>. This deflection has been attributed to delayed depolarization, to a current of injury, or to early repolarization. In leads that face the left ventricle, the deflection is positive and its size is inversely related to body temperature <citationref linkend="CIT0006">6</citationref>. The earliest morphologic abnormality in patients with mild hypothermia is a tremor artifact due to the shiver response. This is non-specific and becomes uncommon at core body temperatures less than 32&deg;C as the body&apos;s ability to generate a shiver response diminishes. As core body temperature approaches moderate hypothermia, we find the appearance of the J waves. J waves can be considered highly suggestive of hypothermia but are not considered to be pathognomonic <citationref linkend="CIT0003">3</citationref>. Conditions other than hypothermia have been reported to cause an abnormal J wave deflection such as hypercalcemia, brain injury, subarachnoid hemorrhage, damage to sympathetic nerves in the neck, and cardiopulmonary arrest from oversedation <citationref linkend="CIT0002">2</citationref>. A deflection similar to the J wave is also present in patients with Brugada syndrome <citationref linkend="CIT0007">7</citationref>. J waves have no relationship to pH, sodium, potassium, or chloride concentrations <citationref linkend="CIT0003">3</citationref>.</para>
	</section1>
	<section1 id="S0001" doi="10.3402/jchimp.v1i4.10742-S0001">
		<title>Conflict of interest and funding</title>
		<para>The authors have not received any funding or benefits from industry or elsewhere to conduct this study.</para>
	</section1>
	<references article-association="a010742">
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